Mdi and tdi dermal penetration studies

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This article has been cited by other articles in PMC. Safety, Health and the Environment. Vanoirbeek JA, Tarkowski M, Ceuppens JL, Verbeken EK, Nemery B, Hoet PH. Human isocyanate skin absorption likely depends on a number of factors, in addition to the extent of isocyanate skin exposure, and may vary between isocyanates because of differences in their physical and chemical properties, including molecular mass, fat solubility, and chemical reactivity. International Symposium on Biological Monitoring in Occupational and Environmental Health, 11—13 September , Espoo, Finland. Skin as a route of exposure to protein allergens.
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Proceedings of the American Thoracic Society

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4,4'-methylenediphenyl diisocyanate - Registration Dossier - ECHA

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Dermal uptake and excretion of 14C-toluene diisocyante (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. Clinical signs and histopathology following dermal exposure of male rats to TDI

In the UK, a management control system is required for workers exposed to isocyanates and for this to be successful workers should not become sensitized. Occupational health professionals should be aware that HSE is conducting a series of safety and health awareness days for workers potentially exposed to isocyanates in motor vehicle repair and has produced new guidance documents that emphasize the need to control exposures to isocyanates and to use biological monitoring to check that the controls work [ 22—24 ]. A similar role for human skin exposure to certain sensitizing agents, such as isocyanates, is likely. Considerable amounts of the applied radioactivity were found at the application site which.
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